Tuesday, December 6, 2011

EU in antitrust probe of Apple, e-book publishers (AP)

BRUSSELS ? The European Union's antitrust watchdog is probing whether Apple and five major publishing houses have colluded to restrict competition in the market for e-books.

The European Commission probe announced Tuesday focuses on potentially anticompetitive practices by publishers Hachette Livre, a unit of France's Lagardere Publishing; Harper Collins, owned by Rupert Murdoch's U.S.-based News Corp.; CBS Corp.'s Simon & Schuster; Penguin, which is owned by U.K. publishing house Pearson Group; and Germany's Verlagsgruppe Georg von Holtzbrinck.

"The Commission will in particular investigate whether these publishing groups and Apple have engaged in illegal agreements or practices that would have the object or the effect of restricting competition" in Europe, it said in a statement.

It is also looking into "agency agreements" between the publishers and the e-book retailers. In those agreements, publishers set a price for their e-books, with retailers taking a cut of the profits.

Apple Inc. runs the iBook online store, in which consumers can buy and download e-books onto the company's devices, including the popular iPad tablet and the iPhone. It is a competitor of Amazon.com Inc.

The announcement from the Commission follows raids in the offices of several publishers in March and a related probe launched by the U.K. Office of Fair Trading. The Commission said Tuesday that the British agency OFT had suspended its investigation since the Commission had taken over the case, but the two regulators were working closely together.

Pearson said that the fact that the Commission has opened an investigation does not prejudge the outcome of the probe.

"Pearson does not believe it has breached any laws, and will continue to fully and openly cooperarte with the Commission," the company said in a statement.

___

Robert Barr in London contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/ap/20111206/ap_on_hi_te/eu_ebooks_antitrust_probe

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Tiny genetic variation can predict ovarian cancer outcome ...

Yale Cancer Center researchers have shown that a tiny genetic variation predicts chances of survival and response to treatment for patients with ovarian cancer.

The findings, published in the journal Oncogene, provide new insights into the biology of a new class of cancer marker and suggest a genetic test may help guide the treatment of women with ovarian cancer.

?This gives us a way to identify which women are at highest risk for resistance to platinum chemotherapy, the standard treatment for ovarian cancer, and helps identify ovarian cancer patients with the worst outcomes,? said Joanne Weidhaas, associate professor of therapeutic radiology and senior author of the study. ?There just aren?t many inherited gene variants than can do that.?

Women who possess the biomarker identified by the Yale team ? a variant of the well-known KRAS oncogene ? are three times more resistant to standard platinum chemotherapy than women without the variant. Also, post-menopausal women with the variant are significantly more likely to die from ovarian cancer. About 12-15 percent of Caucasians and 6 percent of African-Americans are born with the variant of the gene, which helps regulate destruction of damaged cells. This variant is found in up to 25% of newly diagnosed ovarian cancer patients.

Although good alternatives to chemotherapy are not yet available for women with ovarian cancer and this variant, several drugs in development which target the KRAS gene and associated pathways have shown great promise, Weidhaas said.

Weidhaas is a co-founder of a company that has licensed intellectual property from Yale that has developed a diagnostic test based on the Kras-variant.

The biomarker intrigues scientists because it is a functional variant in an area of DNA that does not code for proteins. Instead this variant disrupts how a microRNA controls gene expression.

?This is a new paradigm,? Weidhaas said.

Yale researchers have also found this microRNA variant of the KRAS gene is associated with an increased risk of developing breast cancer and lung cancer. Other researchers have found associations with poor outcome in colon as well as head and neck cancers.

In laboratory tests, researchers blocked the variant and significantly reduced growth of ovarian cancer cells. This suggests targeting the variant site may someday help treat cancer in these patients.

The study was funded by the NIH, the National Cancer Institute and the Merkel Foundation.

Other Yale authors are Elena S. Ratner, Florence K. Keane, Michelle Glasgow, Sunitha Nallur, Yanhong Deng, Stefania Bellone, Marta Boeke, Xiaopan Yao, Daniel Zelterman, Herbert Yu, Thomas J. Rutherford, Peter E. Schwartz, Frank J. Slack and Alessandro D. Santin.

Source: http://scienceblog.com/50009/tiny-genetic-variation-can-predict-ovarian-cancer-outcome/

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Monday, December 5, 2011

Debt and doubt loom large over Durban climate talks (Reuters)

DURBAN, South Africa (Reuters) ? Economic crisis and the top three polluters China, the United States and India, loomed as obstacles to a new global deal at the start of a second make-or-break week of U.N. climate talks in the South African city of Durban.

After a first week of preliminary discussion, serious doubt hangs over the future of the Kyoto Protocol, whose first commitment period on tackling climate change expires at the end of next year.

The other major issue for debate is how to drum up finance to help poorer nations adapt to a warmer planet, while the developed world wrestles with sovereign debt problems.

China, the world's biggest carbon emitter, gave a lift to the climate talks at the end of last week by suggesting it might sign up to a legally-binding deal to cut emissions, but it has set conditions.

"China has talked about a legally binding deal after 2020. The question is if China will be legally-bound. That would be interesting," EU Climate Commissioner Connie Hedegaard said.

China failed to answer that question at a news conference and a European diplomatic source said it was bluffing.

"There's no way China will sign up legally, but it doesn't want to be blamed if the talks fail," the source said, asking not to be named.

China's conditions include that other big emitters sign up and that finance is provided under a Green Climate Fund agreed at talks last year in Cancun, which aims to channel up to $100 billion a year by 2020 to help developing nations.

The U.S. special envoy for climate change Todd Stern said China's conditions were not acceptable.

"In order for there to be a legally-binding agreement that makes sense, all the major players are going to have to be in with obligations and commitments that have the same legal force," Stern said.

"That means no conditionality, no condition of receiving the financing, no trap doors, no Swiss cheese (with holes) kind of agreement."

In the United States, the second largest global emitter, environmental issues have become a flashpoint for argument between President Barack Obama's Democrats and the Republicans. A reluctant upper house, which failed to pass a climate bill last year, would block any deal to revive Kyoto.

The United States signed, but did not ratify Kyoto. One of its issues is that the boundaries between developed and developing nations have shifted and all big emitters should now be included on an equal basis in any new agreement.

India, the third biggest carbon emitter, has also stated it is not ready for a new binding agreement.

It argues its economic development is not as strong as China's and it should not be asked to take on legal targets for cutting emissions.

Neither India nor China is included in the goals set under the first commitment phase of the Kyoto Protocol, as they were regarded as developing when it was adopted in 1997.

The European Union has sought to take a lead in breaking the deadlock by promising to back a new agreement, but it too has a condition. It wants guarantees, which it has labeled a road map, that other big emitters will sign up too.

"Europe only accounts for 11 percent of global emissions, therefore a second commitment period with only Europe and a few other countries, it's hard to see how anybody could label that a huge achievement for the climate," Hedegaard said.

FOCUS ON ECONOMIC CRISIS

Europe's leadership has been undermined by the huge strain it is under from a sovereign debt crisis that is threatening to destroy the euro.

It is hoped a credible plan to prop up the single currency will emerge at an EU summit on Friday, also the last day of the UN climate talks in Durban.

"Negotiators can't look for a new angle from prime ministers on Friday as they can't take their focus off the eurozone crisis," said Alden Meyer, director of strategy and policy at the Union of Concerned Scientists. "That's the only issue on the agenda."

Negotiators have said there is no longer time to get new commitments sealed before the Kyoto Protocol's commitment period runs out at the end of the year, so they are instead aiming to agree on when new commitments can be forged.

The EU's aim is for a deal by 2015 to take effect by 2020 at the latest. The Kyoto Protocol only came into force eight years after it was adopted.

The commitment period for the developed nations to cut emissions by a minimum of five percent is just one clause in the Kyoto Protocol, the companion legislation to the United Nations Framework Convention on Climate Change (UNFCCC).

Without a new commitment period, the rest of the related agreements remain intact, but do not enforce action on lowering emissions.

South Africa, as host to the climate talks, is keen for another Kyoto Protocol, but is aligned with nations arguing that historically it has been responsible for very little of the pollution that is overheating the planet.

Now, it is among those most vulnerable to drought and crop failure associated with a warmer climate.

Underlying the need for urgent action to cap further temperature change, a report UK Met Office report released in Durban on Monday forecast global temperature would rise between three and five degrees Celsius this century if emissions are left unchecked.

A study released on Sunday found that even in a weak global economy emissions, which hit record levels last year, were still rising.

(Additional reporting by Agnieszka Flak, Jon Herskovitz, Michael Szabo, Andrew Allan; editing by Philippa Fletcher)

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/nm/20111205/wl_nm/us_climate

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Debt funds needed in all eurozone states: Germany (Reuters)

BERLIN (Reuters) ? Every country in the euro zone needs to set up a special national fund for sovereign debt that is more than 60 percent of gross domestic product, Germany's finance minister told a newspaper.

Wolfgang Schaeuble, detailing a proposal he will make at a European Union summit on December 9, told the Passauer Neue Presse that a total of 500 billion euros ($672 billion) would need to go into the German fund.

"We need a redemption fund in every single country of the euro zone," he told the newspaper in comments released on Saturday.

Tax revenues should be used to support the funds, Schaeuble said, adding that Germany would not need to raise taxes to implement the plan.

"Around 500 billion euros needs to be stored in the fund. This affects federal, state and municipal debt," he said.

German Chancellor Angela Merkel believes Schaeuble's proposal could help restore confidence in the euro, her spokesman said on Friday.

"The chancellor welcomes the proposal of introducing national redemption funds as very interesting," Steffen Seibert told a news conference.

Merkel has ruled out the idea of common euro zone debt issuance as a way to restore confidence in the currency bloc and Schaeuble again underlined Germany's opposition in the newspaper interview.

"There cannot be euro bonds. The German economy would be overburdened should we have to guarantee the debts of all the states. On top of this, the necessary pressure on countries to sort out their national debt problems would fall by the wayside.

If all were to keep to the stability criteria, then the problem is solved by itself."

Asked whether the European Central Bank's recent bond buying activities could increase inflation risks, Schaeuble said there was no reason to fear this.

"Serious economists see neither risk nor signs of inflation dangers. The euro is stable, inside and out."

He also rejected the idea of kicking Greece out of the euro zone as a way to help end the crisis.

"We can't just show states the door if they have difficulties. Also, the economic consequences would be totally unforeseeable were one or more countries to leave the euro zone. The vast majority say that this would be the worst of all developments."

($1 = 0.7446 euros)

(Reporting by Sylvia Westall, Editing by Chizu Nomiyama)

Source: http://us.rd.yahoo.com/dailynews/rss/economy/*http%3A//news.yahoo.com/s/nm/20111203/bs_nm/us_germany_eurozone_fimmin

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Saturday, December 3, 2011

Video: CNBC Business News Headlines

CNBC's Brian Shactman reports on today's top business news headlines, including a possible bid to buy Yahoo; Disney bumps up its dividend by 50%; the S&P downgrades Hewlett Packard; and tenative four year deal at Boeing with its machinists union.

Related Links:

Business & financial news headlines from msnbc.com

Source: http://video.msnbc.msn.com/cnbc/45500994/

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South African debuts AIDS film on World AIDS Day (AP)

JOHANNESBURG ? A film opening on World AIDS Day Thursday that mixes live action and animation is taking viewers inside a soccer player's body, showing how he becomes infected with HIV and spreads the virus.

The cast and characters are Kenyan, Nigerian and South African ? which producers hope will help the movie travel across the continent hardest hit by the disease. The pull of soccer, which has a unique power to unite Africans, also should help.

Harriet Gavshon, a producer who worked on "Inside Story: The Science of HIV/AIDS," said the "toxic combination" of death and sex still makes it difficult for people to discuss AIDS.

"You have to constantly find new ways of trying to talk about it," she said.

The 90-minute film, aimed at viewers from their mid-teens and up, is a co-production of Johannesburg's Curious Pictures and an international development program sponsored by the U.S. reality and educational TV company Discovery.

Thursday's premiere at a Johannesburg multiplex will be followed by a U.S. debut in January in Washington and one in Nigeria later next year.

Aric Noboa, president of Discovery Channel Global Education Partnership, said they hope to broadcast the film and distribute DVDS, along with booklets to help guide community leaders in conducting post-film discussions.

Films, TV and radio shows, newspaper ads and billboards can get conversations started. But experts at loveLife, a group that has pioneered a range of programs to teach young South Africans about AIDS, say changing behavior requires keeping the dialogue going long enough for lifesaving messages to sink in.

It appears, though, that messages are getting across in South Africa, at least to young people targeted by projects like "Inside Story." Results released this week from a South African health ministry survey found that infections among 15- to 24-year-olds had dropped from 23.1 percent in 2001 to 21.8 percent in 2010.

But across all age groups, infections are creeping up, and this country of 50 million that has more people ? at least 5.5 million ? living with HIV than in any other country.

The focus on prevention may be becoming even more important. The cost of treatment is increasing as more people test and go on drugs, and efforts to find a cure or vaccine are advancing slowly and fitfully.

According to a U.N. report released on the eve of World AIDS Day, funding for HIV programs dropped from $15.9 billion in 2009 to $15 billion in 2010, well below the estimated $22 billion to $24 billion the U.N. says is needed in 2015 for a comprehensive global response. The report cited the global economic crisis and concerns about the sustainability of the AIDS response, given the increasing costs of treatment and prevention.

Last week, the Global Fund to Fight AIDS, Tuberculosis and Malaria declared it had run out of money to pay for new health programs in the next two years. The fund currently pays for AIDS drugs for about half of the world's HIV patients in developing countries.

It took five years and $2 million ? raised from the U.S. and South African governments, the U.N. AIDS agency and other donors ? to put together "Inside Story."

Since 1997, Discovery Channel Global Education Partnership has been getting educational TV to impoverished communities. Noboa said "Inside Story" grew out of requests from teachers in Africa and elsewhere for more information about AIDS.

The problem is confounded in South Africa by years of misinformation from a president, Thabo Mbeki, who questioned the link between HIV and AIDS, and a health minister, Manto Tshabalala-Msimang, who promoted a "treatment" of beets and garlic.

"I think the issues that were part and parcel of the Mbeki era are still there, they still linger on," said Dr. Dave Spencer, a program director at Right to Care, which provides treatment for thousands of HIV-positive South Africans.

A doctor can prescribe AIDS medication and see a patient grow stronger and healthier. Campaigners trying to change the behavior that leads to infection can never be sure their message is getting across.

"It's so hard to know where exactly we are in the fight," said the director of "Inside Story," Rolie Nikiwe. "It's a frustrating fight, but it's one that needs to be fought."

___

AP Medical Writer Maria Cheng contributed to this report from London.

____

Donna Bryson can be reached on http://twitter.com/dbrysonAP

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111201/ap_on_en_mo/af_south_africa_aids_movie

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Friday, December 2, 2011

Clinton challenges Myanmar to expand reforms (AP)

YANGON, Myanmar ? U.S. Secretary of State Hillary Rodham Clinton on Thursday challenged the leaders of Myanmar to continue and expand upon recent reforms, calling for the release of all political prisoners, an end to violent campaigns against ethnic minorities and a breaking of military ties with North Korea.

"We believe that any political prisoner anywhere should be released," Clinton told reporters during the first visit to this long-isolated nation by the top U.S. diplomat in more than 50 years. "One political prisoner is one too many in our view."

Clinton made her comments ahead of a meeting with the most famous political prisoner of all, opposition leader and Nobel laureate Aung San Suu Kyi, who was released last year after two decades of on-and-off imprisonment and has said she will run in upcoming elections. Clinton and Suu Kyi had a private one-on-one dinner on Thursday and were to see each other again more formally on Friday.

Meeting earlier Thursday with President Thein Sein and other senior government officials in the capital of Naypyidaw, Clinton offered a small package of rewards for steps it had already taken but made clear that more must be done and said the U.S. was not ready to lift sanctions on the country. She hand-delivered letters from President Barack Obama to Thein Sein and Suu Kyi in which Obama expressed hope that relations could further improve.

"I came to assess whether the time is right for a new chapter in our shared history," Clinton said, adding that the U.S. was ready to further improve relations with the civilian government in the Southeast Asian nation ? also known as Burma ? but only if it stays on the path of democratization.

In a series of modest first steps, she announced that Washington would allow Myanmar's participation in a U.S.-backed grouping of Mekong River countries; no longer block enhanced cooperation between the country and the International Monetary Fund; and support intensified U.N. health, microfinance and counternarcotics programs.

A senior U.S. official said Thein Sein had outlined his government's plans for reform in a 45-minute presentation in which he acknowledged that Myanmar lacked a recent tradition of democracy and openness. He asked for U.S. help in making the transition from military to full civilian rule, according to the official, who spoke on condition of anonymity to describe the private diplomatic exchange.

Clinton replied that she was visiting because the U.S. was "encouraged by the steps that you and your government have taken to provide for your people."

Yet, she also made clear that those steps must be consolidated and enlarged if the U.S. is to consider easing near-blanket economic sanctions that block almost all American commercial transactions with Myanmar. "While measures already taken may be unprecedented and certainly welcome, they are just a beginning," she told reporters.

"We're not at the point yet where we can consider lifting sanctions that we have in place because of our ongoing concerns about policies that have to be reversed," Clinton said. "But any steps that the government takes will be carefully considered and will be matched."

She called for the release of political prisoners and an end to brutal ethnic violence that has ravaged the nation for decades. She also warned the country's leadership to break suspected illicit military, nuclear and ballistic missile cooperation with North Korea that may violate U.N. sanctions. "Better relations with the United States will only be possible if the entire government respects the international consensus against the spread of nuclear weapons ... and we support the government's stated intention to sever military ties with North Korea," she said.

In his presentation, Thein Sein vowed that Myanmar would uphold its U.N. obligations with respect to North Korea, according to the senior U.S. official. He also told Clinton that Myanmar was actively considering signing a new agreement with the U.N. nuclear watchdog that would allow unfettered inspections of atomic sites in the country, the official said.

Nyan Win, a spokesman for Suu Kyi's National League for Democracy party, welcomed the U.S. package of rewards and said, "The incentives will help promote better relations and a better future for the country and I hope the government will expand its reform process."

Clinton rejected the idea that the U.S. outreach to Myanmar was partially motivated by the growing influence of China. "We are not viewing this in light of any competition with China," she said. "We are viewing it as an opportunity for us to re-engage here."

"We welcome positive constructive relations between China and her neighbors. We think that is in China's interest as well as in the neighborhood's interest," she said.

Recalling Obama's mention of "flickers of progress" in Myanmar when he announced that Clinton would visit the country, Clinton urged the leadership not to allow them to "be stamped out."

"It will be up to the leaders and the people to fan flickers of progress into flames of freedom that light the path toward a better future," she said. "That ? and nothing less ? is what it will take for us to turn a solitary visit into a lasting partnership."

Before dinner with Suu Kyi, Clinton toured the Shwedagon Pagoda, a 2,500-year-old Buddhist temple with a massive golden stupa.

Despite the historic nature of Clinton's visit, enthusiasm has been muted within Myanmar.

Chan Tun, a 91-year-old veteran politician and a retired ambassador to China, said: "This is a very critical visit because U.S. will understand Myanmar better through engagement. U.S. engagement will also help Myanmar's dependence on China."

But Clinton's presence has been overshadowed by the arrival Thursday of the prime minister of Belarus and his wife, to whom two large welcoming signs were erected at the airport and the road into the city. No such displays welcomed Clinton.

The Belarus Prime Minister made the front page of Thursday's edition of the government-run New Light of Myanmar newspaper. Clinton's visit was mentioned in a two-paragraph story on page 2.

Still, some in Myanmar welcomed the attention from the U.S. "I watched the arrival of Ms. Clinton on Myanmar TV last night," 35-year-old taxi driver Thein Zaw said. "I am very happy that Ms. Clinton is visiting our country because America knows our small country, whether it is good or bad."

___

Associated Press writer Aye Aye Win in Yangon contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20111201/ap_on_re_as/as_clinton_myanmar

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